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3 Background Psoriasis results from a complex interaction of the immune cells, skin cells, and inflammatory messengers called cytokines, resulting in an inflammatory cascade that affects not only the skin but tissues throughout the body (Monteleone 2011

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In melanoma models, NAC supplementation was shown to restore effector function in exhausted T cells during adoptive T cell therapy, primarily through activation of the PI3K/Akt pathway and suppression of Foxo transcription factors [49]